ea0011p203 | Clinical practise and governance | ECE2006
Donadio F
, Angioni AR
, Lania A
, Orsi E
, Beck-Peccoz P
, Spada A
Prolactin (PRL) exists in different forms in human serum. The predominant form is little PRL (23 kDa) with smaller amounts of big PRL (5060 kDa), that may be also associated with big big PRL (bbPRL) or macroprolactin (150170 kDa). A lower biological activity in vivo of bbPRL was reported. Aim of the study was to evaluate the clinical impact of macroprolactin and the association between macroprolactinaemia and polycystic ovary syndrome (PCOS). A group of 115 ...